* {
    margin: 0;
    padding: 0;
    outline: none;
    list-style: none;
    border: none;
    text-decoration: none;

    box-sizing: border-box;
    -webkit-box-sizing: border-box;
    -moz-box-sizing: border-box;
}

html,
body {
    width: 100%;
    height: 100%;
    scroll-behavior: smooth;
    background-color: white;
    overflow: hidden;
    -webkit-overflow-scrolling: touch
}

body {
    overflow-y: hidden;
    -moz-osx-font-smoothing: grayscale;
    -webkit-font-smoothing: subpixel-antialiased !important;
    text-rendering: optimizeLegibility !important;
}

.hide {
    opacity: 0 !important;
}

.hidden {
    display: none !important;
}

img {
    width: 100%;
    height: auto;
}

p,
span,
a,
li,
input,
label,
textarea {
    font-family: 'sora-regular';
    font-weight: 500;
    line-height: 1.2;
}

h5 {
    font-family: 'sora-regular';
    font-weight: 500;
    line-height: 1.1;
}

h1,
h4,
h3 {
    font-family: 'sora-bold';
    line-height: 1.1;
}

h1 {
    font-size: 9vw;
}

h2,
h2 span {
    font-family: 'sora-semibold';
    line-height: 1.1;
    margin-bottom: 5%;
    font-size: 7vw;
}

h2 span {
    font-size: 5.8vw;
}

h3 {
    font-size: 4.2vw;
}

.smallerh3 {
    font-size: 4vw;
}

h3+h3 {
    margin-top: 2%;
}

.div_margin_top h2 {
    margin-top: 10%;
}

h4 {
    font-size: 3.8vw;
}

h5 {
    font-size: 3.7vw;
}

sup {
    line-height: 0;
    font-size: xx-small;
}

p,
span,
a,
li,
input,
label,
textarea {
    font-size: 2.5vw;
}

p sup,
span sup,
a sup,
li sup {
    font-size: 1.5vw;
}

.w100 {
    width: 100%;
}

.bold,
strong,
#submit {
    font-family: 'sora-bold';
}

.extra-bold {
    font-family: 'sora-extrabold';
}

.extra-light {
    font-family: 'sora-extralight';
}

.italic {
    font-family: 'sora-italic';
    font-weight: 100;
}

.light {
    font-family: 'sora-light';
    font-weight: 100;
}

.light-italic {
    font-family: 'sora-lightitalic';
    font-weight: 100;
}

.medium {
    font-family: 'sora-medium';
}

.medium-italic {
    font-family: 'sora-mediumitalic';
}

.regular {
    font-family: 'sora-regular';
    font-weight: 500;
}

.semibold {
    font-family: 'sora-semibold';
}

.thin {
    font-family: 'sora-thin';
    font-weight: 100;
}

.text-center {
    text-align: center;
}

.text-left {
    text-align: left;
}

.ui-loader {
    opacity: 0
}

.blue {
    color: #08107a
}

.white {
    color: #ffffff;
}

.purple {
    color: #250e62;
}

.black {
    color: #000000 !important;
}

.line {
    width: 100%;
    position: relative;
    margin: 5% 0;
    background-color: #48357b;
    height: 0.1%;
}

.vertical-top {
    vertical-align: top !important;
}

.mt1_5 {
    margin-top: 1.5% !important;
}

.mt2_5 {
    margin-top: 2.5% !important;
}

.mt5 {
    margin-top: 5% !important;
}

.mb1_5 {
    margin-bottom: 1.5% !important;
}

.mb2_5 {
    margin-bottom: 2.5% !important;
}

.mb5 {
    margin-bottom: 5% !important;
}

.mb10 {
    margin-bottom: 10% !important;
}

.flex_column {
    display: flex;
    flex-direction: column;
}

.flex_2_row {
    display: flex;
}

/* back to top */
#scroll {
    position: fixed;
    right: 5%;
    bottom: 5%;
    cursor: pointer;
    width: 40px;
    height: 40px;
    background-color: #00857C;
    text-indent: -9999px;
    display: none;
    -webkit-border-radius: 5px;
    -moz-border-radius: 5px;
    border-radius: 5px;
}

#scroll span {
    position: absolute;
    top: 50%;
    left: 50%;
    margin-left: -8px;
    margin-top: -12px;
    height: 0;
    width: 0;
    border: 8px solid transparent;
    border-bottom-color: #ffffff
}

#scroll:hover {
    background-color: #C81765;
    opacity: 1;
    filter: "alpha(opacity=100)";
    -ms-filter: "alpha(opacity=100)";
}

/* Header */
.header-main-menu img {
    width: 35%;
    max-width: 115px;
}

.header-main-menu#main_header {
    padding: 0
}

.header-main-menu {
    position: fixed;
    display: flex;
    align-items: center;
    top: 0;
    flex-direction: column;
    width: 100%;
    height: 0%;
    z-index: 99;
    transition: all 0.7s ease;
}

.header_top {
    display: flex;
    align-items: center;
    width: 100%;
    padding: 0.5em;
    background-color: #c9f5ff;
    z-index: 99;
}

.header_top>a {
    width: 100%;
}

/* Hamburger */
.hamburger {
    position: relative;
    display: block;
    z-index: 99;
    float: right;
    /* transform: scale(1.4); */
}

.hamburger .line {
    width: 30px;
    height: 1px;
    background-color: #271164;
    display: block;
    margin: 8px;
    -webkit-transition: all 0.3s ease-in-out;
    -o-transition: all 0.3s ease-in-out;
    transition: all 0.3s ease-in-out;
}

.hamburger:hover {
    cursor: pointer;
}

/* hamburger animation */
#hamburger-1.is-active .line:nth-child(2) {
    opacity: 0;
}

#hamburger-1.is-active .line:nth-child(1) {
    -webkit-transform: translateY(10px) rotate(45deg);
    -ms-transform: translateY(10px) rotate(45deg);
    -o-transform: translateY(10px) rotate(45deg);
    transform: translateY(10px) rotate(45deg);
}

#hamburger-1.is-active .line:nth-child(3) {
    -webkit-transform: translateY(-8px) rotate(-45deg);
    -ms-transform: translateY(-8px) rotate(-45deg);
    -o-transform: translateY(-8px) rotate(-45deg);
    transform: translateY(-8px) rotate(-45deg);
}

/* hamburger animation END */

nav {
    position: relative;
    display: block;
    width: 100%;
    height: 100%;
    top: -300vw;
    right: 0;
    transition: all 0.7s ease;
    opacity: 0;
    z-index: -1;
    background-color: #250e62;
}

nav ul {
    /* position: fixed; */
    height: 88vh;
    display: flex;
    position: relative;
    flex-direction: column;
    align-items: flex-start;
    justify-content: center;
}

ul.sub-menu.active {
    display: block;
}

nav ul.sub-menu li+li {
    margin-top: 2%;
}

nav ul.sub-menu li {
    width: 100%;
}

nav ul.sub-menu .middle {
    margin: 5% 0;
}

nav ul li {
    border-bottom: 1px solid white;
    padding: 1em;
}

nav ul li:last-child {
    border-bottom: transparent;
}

nav ul li a {
    text-decoration: none;
    color: white;
    font-size: 5vw;
    font-family: 'sora-regular';
    font-weight: 500;
    text-align: center;
}

nav ul li:nth-child(2),
nav ul li:nth-child(4) {
    margin: 0;
}

nav ul li ul li a {
    font-weight: normal;
    font-family: 'sora-regular';
    font-weight: 500;
}

.sub a {
    font-size: 2vw;
    font-weight: normal;
}

ul.sub-menu {
    padding: 0.5em 2em;
}

ul.sub-menu li.sub-nav-item:nth-child(2) a {
    border-top: 1px solid #250e62;
}

ul.sub-menu ul.sub-menu li {
    position: absolute;
    left: -20vw;
    width: 90%;
    margin: 3% auto;
    padding: 0em 0em;
    opacity: 0;
    visibility: hidden;
    transition-property: all;
    transition-timing-function: ease;
    transition-duration: 0.5s;
}

ul.sub-menu ul.sub-menu.active li {
    position: relative;
    left: 0vw;
    opacity: 1;
    visibility: visible;
    transition-property: all;
    transition-timing-function: ease;
    transition-duration: 0.5s;
}

/* Header END */

.back_button_holder {
    display: none;
}

/* loading screen */
.overlay {
    position: fixed;
    top: 0;
    left: 0;
    width: 100%;
    height: 100%;
    z-index: 100000000;
    /* background-image: url(img/bg.jpg); */
    background-color: white;
    background-repeat: no-repeat;
    background-size: 100% 100%;
    transition: 2s opacity ease-out;
    display: flex;
    align-items: center;
    justify-content: center;
}

.overlayContent {
    position: relative;
    width: 100%;
    height: 100%;
    padding: 0 0.4em;
    background-color: rgba(37, 14, 98, 0.5);
    display: flex;
    justify-content: center;
    align-items: center;
    flex-direction: column;
    transition: .5s cubic-bezier(.77, 0, .18, 1)
}

.loading {
    display: block;
    text-align: center;
    font-weight: 400;
    transition: 0.2s ease;
}

.loading h4 {
    color: #ffffff;
    font-size: 5vw;
    animation: fade 2s ease infinite;
    font-family: 'sora-bold';
}

.loading img {
    width: 50%;
    margin-bottom: 5%;
    filter: drop-shadow(0.1rem 0.1rem 0.3rem rgba(222, 113, 110, 0.5));
    opacity: 0;
}

@keyframes fade {
    0% {
        opacity: 1
    }

    50% {
        opacity: 0
    }

    100% {
        opacity: 1
    }
}

@-webkit-keyframes fade {
    0% {
        opacity: 1
    }

    50% {
        opacity: 0
    }

    100% {
        opacity: 1
    }
}

@-moz-keyframes fade {
    0% {
        opacity: 1
    }

    50% {
        opacity: 0
    }

    100% {
        opacity: 1
    }
}

@-o-keyframes fade {
    0% {
        opacity: 1
    }

    50% {
        opacity: 0
    }

    100% {
        opacity: 1
    }
}

/* loading screen END */

.desktop {
    display: none;
    flex-direction: column;
    align-items: center;
    justify-content: center;
    width: 100%;
    height: 100%;
}

.mobile_landscape {
    display: none;
}

.mobile_show {
    display: none;
}

.show_desktop,
.show_desktop_block {
    display: none !important;
}

.show_mobile {
    display: flex !important;
}

.mobile {
    display: flex;
    flex-direction: column;
    flex-direction: column;
    align-items: center;
    justify-content: center;
    width: 100%;
    height: 100%;
    position: relative;
    z-index: 99;
}

.content {
    display: flex;
    flex-direction: column;
    flex-direction: column;
    align-items: center;
    justify-content: center;
    width: 100%;
    height: 100%;
    position: relative;
    z-index: 99;
}

.home_bg,
.rules,
.word_search_bg {
    background-image: url(./img/home_bg.jpg);
    background-size: 100% 100%;
    background-repeat: no-repeat;
}

.word_search_bg2 {
    background-image: url(./img/word_seach_bg2.png);
    background-size: contain;
    background-repeat: no-repeat;
    background-position: bottom;
    position: absolute;
    bottom: 0;
    right: 0;
    width: 100%;
    height: 100%;
    pointer-events: none;
}

.leaderboard_bg {
    background-image: url(./img/leaderboard_bg.png);
    background-size: 100% 100%;
    background-repeat: no-repeat;
}

.treatment_tolerability_popup_bg {
    background-image: url(./img/treatment_tolerability_popup_bg.png);
    background-size: 100% 100%;
    background-repeat: no-repeat;
}

.treatment_tolerability_popup_bg h5 {
    padding: 1em;
}

.main {
    display: flex;
    flex-direction: column;
    justify-content: center;
    align-items: center;
    width: 100%;
    height: 100%;
    margin: auto;
}

.home,
.rules,
.game,
.leaderboard {
    display: none;
}

body.home-page,
body.about-page,
body.side_effects-page,
body.capitello-page,
body.dosing-page,
body.safety-page,
body.capitello-study-page,
body.event-recordings-page,
body.patient-cases-page {
    overflow: hidden;
}

.header,
.header_no_bg,
.header_password {
    display: flex;
    flex-direction: column;
    justify-content: flex-start;
    align-items: center;
    width: 100%;
    height: 100%;
    padding: 5em 1em;
    background-color: rgba(255, 255, 255, 0.85);
    overflow-y: scroll;
    overflow-x: hidden;
}

.header_no_bg {
    background-color: transparent;
}

.header_password {
    justify-content: center;
}

.top {
    display: flex;
    flex-direction: column;
    align-items: center;
    margin: 10% 0 7% 0;
}

.password_form,
.popup_form,
.name_form,
.play_button,
.play_again_button,
.find_out_more {
    display: flex;
    width: 100%;
    flex-direction: column;
    align-items: center;
    justify-content: center;
}

.find_out_more {
    align-items: flex-start;
}

.play_again_button {
    display: none;
}

input[type=submit],
input[type=text],
.popup_form input,
.play_button p,
.play_again_button p,
.find_out_more p,
.dosing_regimen_click p {
    font-family: 'sora-regular';
    font-weight: 500;
    font-size: 4vw;
    text-align: center;
    padding: 0.5em;
}

input[type=submit],
.popup_form input,
.play_button p,
.play_again_button p,
.find_out_more p,
.dosing_regimen_click p {
    width: 50%;
    color: white;
    background-color: #250e62;
    margin-top: 5%;
    border-radius: 2em;
}

.play_button p,
.play_again_button p {
    width: 60%;
}

input[type=text] {
    margin: 5% 0;
    width: 100%;
    padding: 1em 0.5em;
    color: #250e62;
    background-image: url(./img/submit_bg.png);
    background-size: 100% 100%;
    background-repeat: no-repeat;
    border-radius: 0;
    -webkit-appearance: none;
    appearance: none;
    box-sizing: padding-box;
}

input#submit_name {
    background-color: #cccccc;
}

/* landing page */
.landing01_holder {
    position: absolute;
    width: 100%;
    /* width: 100%;
    height: 100%; */
    top: 0;
    left: 0;
}

.landing01_holder .header {
    background-color: transparent;
}

.landing_logo {
    display: flex;
    flex-direction: column;
    justify-content: flex-start;
    align-items: flex-end;
    width: 95%;
    height: 100%;
    margin-top: 5%;
}

.landing_logo img:first-child {
    width: 35%;
}

.landing_logo img:last-child {
    width: 70%;
    opacity: 0;
}

.top_logo {
    position: fixed;
    width: 100%;
    height: 100%;
    bottom: 0%;
}

.landing01,
.swipe_holder {
    opacity: 1;
    transition: all 0.7s ease;
}

.swipe_holder {
    position: fixed;
    top: 0;
}

.swipe_holder .header {
    padding: 4em 1em;
}

.top_logo img {
    position: absolute;
    bottom: 0;
}

.bottom_swipe {
    position: relative;
    width: 100%;
    height: 100%;
    display: flex;
    justify-content: flex-end;
    align-items: center;
    flex-direction: column;
    opacity: 0;
    transition: all 0.7s ease;
}

.bottom_swipe .show_mobile {
    width: 50%;
}

.disclaimer {
    width: 100%;
    margin-top: 5%;
}

.disclaimer p {
    font-family: 'sora-italic';
    text-align: center;
    font-size: 1.7vw;
}

.disclaimer_landing {
    margin-bottom: 13%;
    width: 98%;
    height: auto;
    z-index: 2;
    position: absolute;
    bottom: 0;
    right: 0;
    opacity: 0;
    display: flex;
    justify-content: flex-start;
    align-items: flex-start;
    transition: all 0.7s ease;
}

.disclaimer_landing p {
    text-align: left;
}

/* popup home page */
.popup.main {
    position: absolute;
    top: 0;
    background-color: rgba(0, 0, 0, 0.5);
}

.popup .header {
    width: 100%;
    background-color: transparent;
    padding: 0;
}

.popup_holder {
    background-color: white;
    padding: 1em;
}

.popup .popup_form {
    flex-direction: row;
    justify-content: flex-end;
}

.popup_form input {
    background-color: #8083c7;
    width: 20%;
}

.popup_form input:hover {
    background-color: #250e62;
}

input.yes {
    background-color: #250e62;
    margin-right: 2%;
}

.no {
    margin-left: 2%;
}

/* Footer */

#footer {
    height: 100%;
    background-color: black;
}

.min-height-footer {
    min-height: 13vw;
}

.footer_holder {
    position: relative;
    width: 80%;
    height: 100%;
    margin: 0 auto;
}

.footer img {
    width: 90%;
    margin: 0 auto;
}

.footer {
    display: flex;
    flex-direction: column;
    position: absolute;
    /* position: relative; */
    width: 100%;
    background: #e6e6f4;
    bottom: 0;
    opacity: 0;
    z-index: 99;
    transition: all 0.7s ease;
}

.footer-home {
    background: transparent;
}

.footer>div>div {
    position: relative;
    display: flex;
    flex-direction: row;
    justify-content: space-between;
    align-items: center;
    padding: 0.5em 0.7em;
}

div.footer {
    display: flex;
    flex-direction: row;
    align-items: center;
    width: 100%;
    background-color: #c9f5ff;
}

.footer p,
.footer a {
    color: #000000;
    font-family: 'sora-regular';
    font-weight: 500;
    line-height: 1.1;
    font-size: 1.5vw;
}

.footer>div>div p:first-child {
    width: 83%;
    background: linear-gradient(to right, transparent 99.7%, #000000 100%);
}

.footer>div>div p:nth-child(2) {
    width: 15%;
}

.footer a {
    text-decoration: none;
}

.footer a:hover {
    text-decoration: none;
}

.underline {
    text-decoration: underline;
}

.footer-item {
    display: flex;
    justify-content: center;
    width: 100%;
}

.footer-item:last-child {
    align-items: center;
}

.footer-item:last-child img {
    width: 50%;
}

.footer-item:last-child a {
    width: 7%;
}

.footer-item img {
    width: 2.5%;
    aspect-ratio: 1;
    object-fit: contain;
}

.footer-item img:nth-child(3) {
    margin: 0 2%;
}

/* Footer END */

/* table */

.table_border {
    border: 1px solid #270e62;
    border-radius: 1em;
    padding: 1em;
}

.blue_table_holder {
    background-color: #e4faff;
}

.blue_table>div:first-child {
    background-color: #250e62;
    padding: 0.5em;
    border-radius: 0em 1em 0em 0em;
}

.blue_table>div:last-child {
    padding: 1.5em 1em;
}

.blue_table_text {
    display: flex;
    padding: 1.5em 1em;
}

.blue_table_text td {
    width: 47%;
}

.blue_table_text td.bullet {
    width: 2%;
    margin-right: 1%;
    max-width: 7px;
}

table {
    width: 100%;
    position: relative;
    display: flex;
    flex-direction: row;
    align-items: center;
}

tbody {
    width: 100%;
    display: flex;
    flex-direction: column;
    justify-content: space-evenly;
}

tr+tr {
    margin-top: 3.5%;
}

tr.no_margin {
    margin-top: 1.5%;
}

tr {
    display: flex;
    justify-content: flex-start;
}

tr:first-child {
    margin-top: 0;
}

span.bullet {
    display: inline-block;
}

.bullet {
    font-size: xx-small;
    vertical-align: top;
    width: 2%;
    max-width: 7px;
    margin-right: 1%;
    color: #f8485e;
    /* vertical-align: middle; */

}

.black_bullet {
    color: #000000;
}

.nested_table {
    margin-left: 4%;
}

.bullet.vertical-top {
    width: 2%;
}

.text {
    width: 97%;
    vertical-align: middle;
}

.inline_block,
.text_image {
    display: inline-block;
}

.text_image img {
    width: 9%;
    vertical-align: middle;
    margin-left: 3%;
}

.text h5 {
    /* margin-left: 3%; */
}

/* icon_holder */
.icon_holder,
.icon_holder_arrow_white,
.icon_holder_plus_white {
    width: 100%;
    position: relative;
    flex-direction: column;
    display: flex;
    margin-top: 10%;
    padding-bottom: 2em;
}

.icon_holder_arrow_white {
    width: 90%;
}

.icon_holder_plus_white {
    align-items: center;
    margin-top: 5%;
}

.icon,
.icon_holder_arrow_white_mobile {
    display: flex;
    width: 100%;
    flex-direction: column;
    align-items: center;
    justify-content: center;
}

.icon_holder_arrow_white_mobile {
    margin-top: 3%;
}

.icon div,
.icon_holder_arrow_white_mobile div {
    width: 100%;
    display: flex;
    flex-direction: row;
    justify-content: flex-start;
    align-items: center;
    background-color: #250e62;
    padding: 0.7em;
    border-radius: 0.5em;
}

.icon_holder_arrow_white_mobile div {
    padding: 0.4em;
}

.icon div img,
.icon_holder_arrow_white_mobile div img {
    width: 100%;
    max-width: 35px;
    padding: 0 0.5em;
}

.icon div h5,
.icon_holder_arrow_white_mobile div h5 {
    padding: 0 0.5em;
}

.icon.ref {
    margin-bottom: 3%;
}

/* popup */
.popup_main {
    position: absolute;
    display: none;
    justify-content: flex-end;
    width: 100%;
    height: 100%;
    background-color: rgba(0, 0, 0, 0.5);
    z-index: 100;
}

.home-ref {
    top: 0;
}

.header_popup {
    display: flex;
    flex-direction: column;
    justify-content: flex-end;
    align-items: center;
    width: 100%;
    height: 94%;
    overflow-y: scroll;
    overflow-x: hidden;
}

.header_popup_top {
    display: flex;
    flex-direction: column;
    justify-content: flex-start;
    align-items: center;
    width: 100%;
    height: 93%;
    overflow-y: scroll;
    overflow-x: hidden;
}

.div_popup {
    width: 100%;
    padding: 2em 0.7em;
    background-color: white;
    overflow-y: scroll;
    overflow-x: hidden;
}

.header_popup .rules,
.header_popup .word_search_bg {
    padding: 2em 1.5em;
}

.div_popup>div:first-child {
    height: 100%;
}

.header_popup .div_popup {
    height: 100%;
    min-height: 500px;
}

.header_popup_top .div_popup {
    height: auto;
    min-height: 250px !important;
}

/* .div_popup h2 {
    font-size: 6vw;
} */

.references a,
h5.light,
.references .text h5,
.div_popup h5.light,
h5 span,
.num_bullet {
    font-size: 3.2vw;
}

.references a {
    text-decoration: none;
    color: #000000;
}

.num_bullet h5 {
    font-size: 4vw;
}

h5.bigger_text {
    font-size: 4vw;
}

.num_bullet {
    font-family: 'sora-semibold';
    width: 4%;
    margin-right: 1%;
    color: #f8485e;
    vertical-align: top;
}

.top_popup {
    width: 100%;
    display: flex;
    flex-direction: row;
    align-items: flex-start;
}

.top_popup>div:first-child {
    width: 94%;
}

.close_holder {
    width: 6%;
    margin-right: 3%;
}

.top_popup .close_holder img {
    width: 100%;
}

/* game */
.game td {
    width: 5%;
    height: 5%;
}

.game_container {
    width: 100%;
    height: auto;
    display: flex;
    justify-content: center;
    flex-direction: column-reverse;
    align-items: center;
}

.game ul {
    display: flex;
    flex-direction: row;
    justify-content: space-between;
    flex-basis: 100%;
    margin: 0;
    padding: 0.5em;
    flex-wrap: wrap;
}

.game li {
    font-size: 3.5vw;
    color: white;
    padding: 0.5em;
    display: block;
    background-color: #f8485e;
    border-radius: 2em;
}

.game li.found {
    background-color: #250e62;
}

.label {
    font-size: 5vw;
}

.list_holder {
    display: flex;
    flex-wrap: wrap;
    width: 100%;
    flex-direction: row;
    justify-content: center;
}

div#canvasContainer {
    width: 100%;
    display: flex;
    justify-content: center;
    align-items: center;
    background-image: url(./img/word_search_game_bg.png);
    background-size: 100% 100%;
    background-repeat: no-repeat;
    padding: 0.5em;
}

#canvas {
    margin: 3% 0;
}

/* Timer */
.timer {
    display: flex;
    font-size: 2vw;
    width: 100%;
    justify-content: center;
    align-items: center;
    margin: 2% 0;
}

.timer span {
    width: 8%;
    font-size: 6vw;
    background-color: #bdbee0;
    padding: 0.1em;
    border-radius: 0.3em;
    text-align: center;
}

#dot {
    background-color: transparent;
}

#mins2,
#seconds {
    margin: 0 0.5%;
}

/* Score */
.score,
.endscore {
    color: black;
    display: flex;
    justify-content: center;
    /* padding-top: 1em; */
}

.endgame {
    display: flex;
    flex-direction: column;
    justify-content: center;
    align-items: flex-end;
    width: 100%;
    height: 85%;
    padding: 2em 1.5em;
}

.endgame span,
.endgame h5 {
    color: #250e62;
    font-family: 'sora-semibold';
}

.score {
    display: flex;
    flex-direction: column;
    align-items: center;
}

.top3 {
    width: 100%;
    display: flex;
    flex-direction: row;
    justify-content: space-evenly;
    align-items: flex-end;
}

.top10 .score h5,
.top10 .score span,
.top3 .score h5,
.top3 .score span {
    font-size: 3.2vw;
}

.top3 .score span:last-child {
    color: white;
}

#score01 h5,
#leaderboard_01,
#leaderboard_01_score {
    font-size: 4.2vw;
}

#score02 img,
#score03 img {
    width: 50%;
}

#score01 img {
    width: 70%;
}

.top3 img {
    margin: 5% 0;
}

.top3 {
    margin-bottom: 2%;
}

.leaderboard_name {
    width: 80%;
    color: #000000;
    text-align: center;
}

.top10 .score h5,
.top10 .score span:last-child {
    color: #f8485e;
}

.top10 .score span:last-child {
    text-align: right;
}

.top10 .score {
    display: flex;
    flex-direction: row;
    justify-content: flex-start;
    background-color: white;
    padding: 0.5em;
    border-radius: 2em;
    margin-top: 2%;
}

.top10 {
    width: 100%;
    display: flex;
    flex-direction: column;
}

/* scroll image */
.image-container {
    width: 100%;
    overflow-x: auto;
}

.image-container img {
    width: 170%;
    height: auto;
}

.image-container2 img {
    width: 270%;
    height: auto;
}

.image-container3 img {
    width: 200%;
    height: auto;
}

/* arrow */
.arrow {
    width: 65%;
}

/* side effects page */
.bluebox {
    width: 100%;
    display: flex;
    align-items: center;
    justify-content: center;
    background-color: #e4faff;
    padding: 1em 1.5em;
    border-radius: 1em;
    margin: 5% 0;
}

.side_effects_less,
.side_effects_less2 {
    width: 100%;
    display: flex;
    flex-direction: row;
    align-items: center;
}

.side_effects_less div:first-child {
    width: 15%;
    margin-right: 5%;
}

.side_effects_less2 div:first-child {
    width: 12%;
    margin-right: 5%;
}

.side_effects3_2_row {
    display: flex;
    justify-content: space-between;
}

.side_effects3_2_row div {
    width: 50%;
}

.side_effects3_2_row div td:last-child {
    width: 95%;
}

/* patient cases */
.patient-cases-blue {
    width: 100%;
    background-color: #e4faff;
}

.patient-cases-blue>h5:first-child,
.patient-cases-blue>h5:nth-child(2),
.patient-cases-blue>h5:nth-child(3) {
    padding: 0.5em 1em;
}

.patient-cases-blue table {
    padding: 1em;
}

.patient-cases-blue .white {
    width: 20%;
    background-color: #250e62;
    border-radius: 0em 0em 1em 0em;
}

.patient-cases-blue2_main {
    width: 100%;
    display: flex;
}

.patient-cases-blue2 {
    width: 50%;
}

.patient-cases-blue2 .num_bullet {
    width: 3%;
    min-width: 10px;
}

/* purple table */
.purple_table {
    width: 100%;
    display: flex;
    align-items: center;
    justify-content: center;
    background-color: #804b92;
}

.purple_table h5 {
    text-align: center;
}

.purple_table div {
    width: 25%;
    padding: 1em;
    display: flex;
    align-items: center;
    justify-content: center;
}

.purple_table_light {
    background-color: #ede3ee;
    align-items: flex-start;
}

.purple_table_light div:last-child {
    flex-direction: column;
}

div.dosing_regimen_click {
    width: 100%;
    margin-top: 0;
    padding: 0;
}

div.dosing_regimen_click p {
    width: 100%;
}

/* Press Enter */
.press_enter {
    margin-top: 5%;
    display: none;
    color: red !important;
}

@media screen and (max-width:350px) and (max-width:365px) {
    /* .bottom_swipe img:first-child {
        height: 75vw;
        opacity: 0;
    } */
}

@media screen and (max-width:600px) {
    .mobile {
        display: flex;
    }

    .mobile_show {
        display: block;
    }

    .mobile_landscape,
    .desktop,
    .message {
        display: none;
    }

    h2,
    h2 span {
        font-size: 7vw;
    }

    h2 span {
        font-size: 5.8vw;
    }

    h3 {
        font-size: 4.2vw;
    }

    .smallerh3 {
        font-size: 4vw;
    }

    h5 {
        font-size: 3.8vw;
    }

    input[type=submit],
    input[type=text],
    .popup_form input,
    .play_button p,
    .play_again_button p,
    .find_out_more p,
    .dosing_regimen_click p {
        font-size: 3.5vw;
    }

    .find_out_more {
        width: 85%;
        margin: 0 auto 0 0;
    }

    .references a,
    h5.light,
    .references .text h5,
    .div_popup h5.light,
    h5 span,
    .num_bullet {
        font-size: 3vw;
    }

    /* Landing */
    .landing_logo img:first-child {
        width: 27%;
    }

    /* .bottom_swipe img:first-child {
        height: 25vw;
        opacity: 0;
    } */

    .bottom_swipe .show_mobile {
        width: 45%;
    }

    .top_logo img {
        position: absolute;
        bottom: 0;
        width: 95%;
    }

    .landing01 {
        display: flex;
        justify-content: center;
    }

    /* main menu */
    nav ul {
        height: 90%;
    }

    nav ul li a {
        text-align: left;
    }

    /* popup */
    .header_popup {
        height: 92%;
    }

    .header_popup_top .div_popup {
        min-height: 200px !important;
    }

    /* word search popup */
    #canvas {
        width: 250px;
        height: 250px;

    }

    .word_search_popup .header_popup {
        height: 100%;
    }

    /* leaderboard */
    .endgame {
        height: 91%;
    }

    /* iframe */
    iframe {
        max-height: 500px;
    }

    iframe.iframe_safety03 {
        max-height: 420px;
    }
}

@media screen and (min-width:601px) {
    .mobile {
        display: flex;
    }

    .mobile_show {
        display: block;
    }

    .mobile_landscape,
    .desktop,
    .message {
        display: none;
    }
}

@media screen and (min-width:768px) {

    .hamburger .line {
        width: 45px;
    }

    .loading h4 {
        font-size: 4vw;
    }

    .home-page h2,
    h2,
    h2 span {
        font-family: 'sora-semibold';
        line-height: 1.1;
        margin-bottom: 5%;
        font-size: 7vw;
    }

    h2 {
        font-size: 5.5vw;
    }

    h2 span {
        font-size: 5.5vw;
    }

    h3 {
        font-size: 3.7vw;
    }

    .smallerh3 {
        font-size: 3.2vw;
    }

    h5 {
        font-size: 3vw;
    }

    .references a,
    h5.light,
    .references .text h5,
    .div_popup h5.light,
    h5 span,
    .num_bullet {
        font-size: 2.5vw;
    }

    .footer p,
    .footer a {
        font-size: 1.3vw;
    }

    input[type=submit],
    input[type=text],
    .popup_form input,
    .play_button p,
    .play_again_button p,
    .find_out_more p,
    .dosing_regimen_click p {
        font-size: 3vw;
    }

    /* nav */
    nav ul li a {
        font-size: 4.5vw;
    }

    /* popup */
    .top_popup .close_holder img {
        width: 80%;
    }

    .close_holder {
        margin-right: 2%;
    }

    /* landing */
    .landing01 {
        display: flex;
        justify-content: center;
    }

    .landing_logo img:first-child {
        width: 30%;
    }

    .top_logo img {
        width: 70%;
    }

    /* .bottom_swipe img:first-child {
        height: 40vw;
    } */

    .bottom_swipe .show_mobile {
        width: 35%;
    }

    /* header menu */
    nav ul {
        height: 100%;
        justify-content: flex-start;
        margin-top: 5%
    }

    /* side-effects */
    .text_image img {
        width: 6%;
        margin-left: 1%;
    }

    .side_effects_less div:first-child {
        width: 10%;
        margin-right: 3%;
    }

    .side_effects_less2 div:first-child {
        width: 12%;
        margin-right: 3%;
    }

    .side_effects_less2 div:first-child img {
        width: auto;
        max-height: 103px;
    }

    /* home */
    .header-main-menu img {
        width: 23%;
        max-width: 160px;
    }

    /* main header div */
    .header,
    .header_no_bg {
        padding: 7em 1em 2em 1em;
    }

    /* icon */
    .icon_holder,
    .icon_holder_arrow_white {
        margin-top: 7%;
        padding-bottom: 5em;
    }

    .icon div {
        padding: 1em;
    }

    .icon div img {
        max-width: 50px;
    }

    /* word search */
    .game li {
        font-size: 3vw;
    }

    div#canvasContainer {
        margin-top: 3%;
        background-size: contain;
        background-position: center;
    }

    .game ul {
        justify-content: space-evenly;
    }

    .timer span {
        width: 6%;
        font-size: 5vw;
    }

    /* image-container */
    .image-container img {
        width: 130%;
    }

    .image-container2 img {
        width: 200%;
    }

    .image-container3 img {
        width: 150%;
    }

    /* leaderboard */
    .endgame {
        padding: 2em 3em;
        height: 88%;
    }

    .top3 {
        margin-bottom: 3%;
    }

    .top10 .score h5,
    .top10 .score span,
    .top3 .score h5,
    .top3 .score span {
        font-size: 2.5vw;
    }

    #score01 h5,
    #leaderboard_01,
    #leaderboard_01_score {
        font-size: 3.5vw;
    }

    #score01 img {
        width: 50%;
    }

    #score02 img,
    #score03 img {
        width: 35%;
    }

    .top10 .score {
        padding: 0.7em 1em;
        margin-top: 1.5%;
    }

    /* blue table */
    .blue_table>div:first-child {
        padding: 1em;
    }

    .blue_table>div:last-child {
        padding: 1.5em 1em;
    }

    /* table */
    .bullet,
    .bullet.vertical-top {
        font-size: small;
    }
}

@media screen and (min-width:200px) and (max-width:992px) {

    /* back to top */
    #scroll {
        width: 30px;
        height: 30px;
    }

    /* nav */
    .dropdown-menu {
        height: auto;
        opacity: 0;
        position: absolute;
        background-color: #e6e6f4;
        width: 100%;
        left: 0;
        z-index: -10;
        margin-top: 2%;
        padding: 0.5em 3em;
    }

    .dropdown-menu li {
        border-bottom: none;
    }

    .dropdown-menu li:nth-child(2) {
        border-top: 1px solid #08107a;
        margin-top: 0;
    }

    .dropdown-menu li a {
        color: #08107a;
    }

    /* side-effect popup */
    .side_effects3_2_row {
        flex-direction: column;
        justify-content: normal
    }

    .side_effects3_2_row div {
        width: 100%;
    }

    /* patient-cases-blue */

    .patient-cases-blue .white {
        width: 30%;
    }

    .patient-cases-blue2_main {
        width: 100%;
        display: flex;
        flex-direction: column;
    }

    .patient-cases-blue2 {
        width: 100%;
        margin: 0 !important;
    }

    .patient-cases-blue2 table {
        padding: 0;
    }

    .patient-cases-blue2:nth-child(1) {
        padding: 1em 1em 0em 1em;
    }

    .patient-cases-blue2:nth-child(2) {
        padding: 0em 1em 1em 1em;
        margin-bottom: 2.5%;
        margin-top: 3.5% !important;
    }

    .purple_table {
        display: block;
        background-color: #804b92
    }

    .purple_table td:first-child {
        background-color: #804b92;
        width: 40%;
        padding: 1em;
        border-top: 2px solid #ffffff;
    }

    .purple_table tr:first-child td:first-child,
    .purple_table tr:nth-child(2) td:first-child {
        border-top: none;
    }

    .purple_table td:nth-child(2) {
        background-color: #ede3ee;
        width: 60%;
        padding: 1em;
        border-bottom: 2px solid #250e62;
    }

    .purple_table tr:last-child td:nth-child(2) {
        border-bottom: none;
    }

    .purple_table table {
        border-spacing: 0;
    }

    .purple_table tr+tr {
        margin: 0;
    }

    .purple_table div {
        width: 100%;
    }

    .purple_table h5 {
        text-align: left;
    }

    .icon_plus_white {
        width: 60%;
        display: flex;
        flex-direction: row;
        justify-content: flex-start;
        align-items: center;
        background-color: #250e62;
        padding: 0.7em;
        border-radius: 0.5em;
    }

    .icon_plus_white div {
        padding: 0.4em;
        width: 100%;
        display: flex;
        align-items: center;
    }

    .icon_plus_white img.plus_white {
        width: 100%;
        max-width: 45px;
        padding: 0 0.5em;
    }

    .mrs-tan-purple-table {
        display: flex;
        flex-direction: row;
        justify-content: center;
    }
}

@media screen and (min-width:600px) and (max-width:768px) {

    .find_out_more {
        width: 85%;
        margin: 0 auto 0 0;
    }
}

/* mobile landscape */
@media screen and (max-width:600px) and (orientation: Landscape) {
    .message {
        display: flex;
    }

    .mobile_landscape {
        display: block;
    }

    .mobile,
    .footer,
    .desktop,
    .mobile_show {
        display: none;
    }
}

/* desktop */
@media screen and (min-width:992px) {

    /* background */
    .home_bg,
    .rules,
    .word_search_bg {
        background-image: url(./img/home_bg2.jpg);
    }

    div#canvasContainer {
        background-image: url(./img/word_search_game_bg_desktop.png);
        background-size: contain;
        padding: 0.5em;
        background-position: center;
    }

    .word_search_bg2 {
        /* background-image: url(./img/word_seach_bg2_desktop.png); */
        background-image: none;
    }

    .header_popup .word_search_bg>div:first-child,
    .header_popup .rules>div:first-child {
        background-image: url(./img/word_seach_bg2_desktop.png);
        background-size: contain;
        background-repeat: no-repeat;
        background-position: right;
        width: 100%;
    }

    .word_search_bg,
    .rules,
    .game,
    .leaderboard {
        height: 800px !important;
    }

    .leaderboard_bg {
        background-image: url(./img/leaderboard_bg_desktop.png);
    }

    body.home-page,
    body.about-page,
    body.side_effects-page,
    body.capitello-page,
    body.dosing-page,
    body.safety-page,
    body.capitello-study-page,
    body.event-recordings-page,
    body.patient-cases-page {
        overflow: hidden;
    }

    .desktop,
    .show_desktop {
        display: flex !important;
    }

    .show_desktop_block {
        display: block !important;
    }

    .mobile_landscape,
    .mobile,
    .mobile_show,
    .show_mobile,
    .message {
        display: none !important;
    }

    h2.home_h2,
    h2 span {
        font-size: 3vw;
        line-height: 1.2;
    }

    h2 {
        font-size: 2.5vw;
        line-height: 1;
    }

    h2 span {
        font-size: 2.8vw;
        line-height: 0.8;
    }

    .header_popup h2 {
        font-size: 2vw;
    }

    h3 {
        font-size: 1.4vw;
    }

    .smallerh3 {
        font-size: 1.35vw;
    }

    h1,
    h2,
    h3,
    h4,
    h5 {
        line-height: 1.3;
    }

    h5 {
        font-size: 1.1vw;
    }

    h5.bigger_text {
        font-size: 1.2vw;
    }

    .references a,
    h5.light,
    .references .text h5,
    .div_popup h5.light,
    .num_bullet,
    h5 span {
        font-size: 0.9vw;
    }

    sup {
        font-size: small;
    }

    h5.light sup,
    h5 sup {
        font-size: 0.6vw;
    }

    p sup,
    h5.light_small sup,
    h5.bold_small sup,
    span sup,
    a sup,
    li sup {
        font-size: 0.4vw;
    }

    .loading h4 {
        font-size: 1.8vw;
    }

    .password_form {
        margin-top: 3%;
    }

    input[type=submit],
    input[type=text],
    .popup_form input,
    .play_button p,
    .play_again_button p,
    .find_out_more p {
        width: 25%;
        font-size: 1.2vw;
        margin-top: 1%;
    }

    input[type=text] {
        width: 75%;
    }

    .play_button p,
    .play_again_button p,
    .find_out_more p {
        width: 85%;
    }

    .dosing_regimen_click p {
        font-size: 1vw;
    }

    .submit_name {
        margin-top: 5% !important;
    }

    input[type=submit] {
        cursor: pointer;
    }

    .popup_form input {
        background-color: #8083c7;
        width: 8%;
    }

    input.yes {
        background-color: #250e62;
        margin-right: 1%;
    }

    .no {
        margin-left: 1%;
    }

    p,
    span,
    a,
    li,
    input,
    label,
    textarea {
        font-size: 1.1vw;
    }

    .footer p,
    .footer a {
        font-size: 0.6vw;
    }

    body.home-page,
    body.about-page,
    body.side_effects-page,
    body.capitello-page,
    body.dosing-page,
    body.safety-page,
    body.capitello-study-page,
    body.event-recordings-page,
    body.patient-cases-page {
        overflow: hidden;
    }

    .header,
    .header_no_bg,
    .header_password {
        padding: 5em 0em;
    }

    .max_desktop {
        /* max-width: 1120px; */
        width: 65% !important;
    }

    .desktop_row {
        width: 100%;
        display: flex;
        flex-direction: row;
        align-items: center;
    }

    .desktop_column {
        display: flex;
        flex-direction: column;
    }

    .desktop_justify_center {
        display: flex;
        justify-content: center;
    }

    .align_start {
        align-items: flex-start !important;
    }

    .justify_center {
        justify-content: center !important;
    }

    .align_end {
        align-items: flex-end !important;
    }

    .middle_popup {
        justify-content: center
    }

    .popup_holder {
        padding: 3em;
    }

    .popup_form {
        margin-top: 5%;
    }

    .div_margin_top h2 {
        margin-top: 5%;
    }

    /* Landing */
    .top {
        align-items: flex-start;
        margin: 2% 0 2% 0;
    }

    .landing_logo img:first-child {
        width: 10%;
    }

    .landing_logo {
        margin-top: 2%;
    }

    .landing_logo img:last-child {
        display: none;
    }

    .landing01_holder .header {
        overflow: hidden;
    }

    .disclaimer_landing {
        margin-bottom: 4%;
    }

    /* .bottom_swipe img:first-child {
        height: 20vw;
    } */

    .bottom_swipe .show_desktop {
        width: 17%;
    }

    #anim01_desktop,
    #anim02_desktop {
        width: 80%;
        max-width: 1300px;
        height: auto;
        /* min-height: 700px; */
    }

    .landing01 {
        display: flex;
        justify-content: center;
    }

    .disclaimer p,
    p.light,
    h5.light_small,
    h5.bold_small {
        font-size: clamp(12px, 0.7vw, 15px);
    }

    h5.bold_small {
        font-family: 'sora-bold';
    }

    .disclaimer_other_pages {
        margin-top: 2%;
        margin-bottom: 2%;
    }

    /* img */
    .img75 {
        width: 75%;
    }

    .img60 {
        width: 60%;
    }

    .img50 {
        width: 50%;
    }

    .img49 {
        width: 49% !important;
    }

    .desktop_row .img49:first-child {
        margin-right: 1%;
    }

    .desktop_row .img49:last-child {
        margin-left: 1%;
    }

    .img40 {
        width: 40%;
    }

    .img30 {
        width: 30%;
    }

    /* padding */
    .right_padding {
        padding: 0em 5em 0em 0em;
    }

    .right_padding10 {
        padding: 0em 10em 0em 0em;
    }

    /* bullet */
    .bullet {
        font-size: 0.85vw;
    }

    .num_bullet {
        width: 1%;
        min-width: 7px;
    }

    .bullet.vertical-top,
    .bullet {
        width: 1%;
        margin-right: 1%;
        min-width: 7px;
    }

    .bullet.vertical-top.bullet_small {
        font-size: 0.5vw;
    }

    .bullet_bigger_margin .bullet {
        margin-right: 5%;
    }

    .bullet_bigger_margin2 .bullet {
        margin-right: 3%;
    }

    /* arrow */
    .arrow {
        width: 85%;
    }

    /* table */

    .two_td2,
    .two_td {
        width: 47%;
    }

    .three_td {
        width: 36%;
    }

    .bullet_bigger_margin {
        width: 100%;
        display: flex;
        flex-direction: row;
        align-items: center;
        justify-content: center;
    }

    .three_td_desktop {
        width: 100%;
        display: flex;
        flex-direction: row;
        justify-content: center;
        margin-right: 5%;
    }

    .blue_table_text td.bullet {
        margin-right: 2%;
    }

    /* home */
    .home_img {
        width: 40%;
        display: flex;
        flex-direction: column;
        justify-content: center;
        align-items: flex-end;
    }

    .home_img img {
        width: 95%;
    }

    /* blue table */
    .blue_table_holder {
        background-color: transparent;
    }

    .blue_table>div:first-child {
        border-radius: 0em 0.7em 0em 0em;
    }

    .blue_table>div:first-child {
        padding: 0.5em 0.5em 0.5em 1.5em;
    }

    .blue_table>div:last-child {
        padding: 1.5em;
    }

    .blue_table_holder>div:first-child,
    .blue_table_holder>div:nth-child(2) {
        background-color: #e4faff;
        border: 1px solid #250e62;
        border-radius: 0em 1em 0em 0em;
        min-height: 250px;
    }

    .blue_table_holder>div:nth-child(2) {
        background-color: transparent;
        margin-left: -2%;
        z-index: -1;
        width: 50%;
    }

    .blue_table_holder>div:nth-child(2)>div {
        background-color: transparent;
        border-bottom: 1px solid #250e62;
    }

    .blue_table_holder.desktop_row {
        align-items: flex-start;
    }

    .blue_table_text {
        padding: 1.5em 3.5em;
    }

    .blue_table_holder>div:nth-child(2)>div h5 {
        padding: 0 1.5em;
    }

    /* blue box */
    .bluebox {
        width: 40%;
        padding: 1.5em;
        margin: 0;
    }

    /* side_effect */
    .text_image img {
        width: 8%;
        margin-left: 2%;
    }

    .side_effects_less div:first-child {
        width: 5%;
        margin-right: 4%;
    }

    .side_effects_less2 div:first-child {
        width: auto;
        margin-right: 4%;
    }

    .side_effects_less2 div:first-child img {
        width: auto;
        max-height: 70px;
    }

    /* line */
    .line {
        margin: 2.5% 0;
        border-top: 1px solid #48357b;
    }

    /* image overflow */
    .image-container img,
    .image-container2 img,
    .image-container3 img {
        width: 100%;
    }

    /* Popup */
    .top_popup .close_holder img,
    .close_game_btn {
        position: absolute;
        top: 0;
        right: 0;
        width: 27px;
        float: right;
    }

    .close_holder {
        margin-right: 0;
        position: relative;
    }

    .word_search_popup .close_holder {
        width: 4%;
    }

    .header_popup_top,
    .header_popup {
        display: flex;
        flex-direction: column;
        justify-content: center;
        align-items: center;
        width: 95%;
        height: 100%;
        overflow: hidden;
    }

    .header_popup_top .div_popup,
    .header_popup .div_popup {
        height: auto;
        min-height: 500px !important;
        max-height: 850px !important;
        width: 65%;
    }

    .header_popup h5 {
        margin-bottom: 0%;
    }

    .header_popup h2 {
        margin-bottom: 2%;
    }

    .div_popup {
        padding: 0;
        overflow: hidden;
    }

    .div_popup>div:first-child,
    .treatment_padding {
        padding: 4em;
    }

    .header_popup .word_search_bg,
    .header_popup .rules,
    .header_popup .game {
        padding: 2em 2em 2em 5em;
    }

    tr+tr {
        margin-top: 2.5%;
    }

    .references tr+tr {
        margin-top: 1%;
    }

    .extend_oral tr+tr {
        margin-top: 1%;
    }

    tr.no_margin {
        margin: 0;
    }

    tr {
        display: flex;
        flex-direction: row;
        justify-content: flex-start;
    }

    .div_margin_top {
        width: 100%;
    }

    /* word search game */
    .header_popup .rules>div:first-child,
    .header_popup .game>div:first-child,
    .header_popup .word_search_bg>div:first-child {
        padding: 0;

    }

    .rules h2,
    .game h2,
    .leaderboard h2 {
        font-size: 2.3vw;
    }

    .rules .num_bullet {
        width: 3%;
    }

    .rules .num_bullet h5,
    .rules .text h5 {
        font-size: 1.2vw;
    }

    .rules .text {
        width: 100%;
    }

    .rules tr+tr {
        margin-top: 2.5%;
    }

    .word_search_bg .desktop_row>div,
    .rules .desktop_row>div {
        width: 50%;
        height: 100%;
    }

    .game .desktop_row>div:first-child {
        width: 45%;
        height: 100%;
    }

    .game .desktop_row>div:last-child {
        display: flex;
        margin-left: 5%;
        width: 55%;
        height: 100%;
    }

    .word_search_bg .desktop_row>div:first-child,
    .rules .desktop_row>div:first-child,
    .game .desktop_row>div:first-child {
        display: flex;
        justify-content: center;
        flex-direction: column;
    }

    .play_button,
    .play_button_again,
    .find_out_more {
        width: 65%;
        margin-left: 3%;
        display: flex;
        align-items: flex-start;
    }

    .find_out_more {
        width: 45%;
        margin-top: 3%;
        margin-left: 0;
    }

    .game li {
        font-size: 1vw;
        text-align: center;
    }

    .list_holder {
        width: 85%;
        justify-content: flex-start;
    }

    #list li:nth-child(4) {
        margin: 3% 0% 0% 0%;
    }

    #list li:nth-child(2) {
        margin: 0% 4%;
    }

    #list li:nth-child(5) {
        margin: 3% 4% 0% 4%;
    }

    .game_container {
        margin-top: 2.5%;
        align-items: flex-start;
    }

    .game ul {
        justify-content: flex-start;
        flex-basis: 100%;
        padding: 0;
    }

    .timer span {
        width: 8%;
        font-size: 1.8vw;
    }

    .timer {
        justify-content: flex-start;
        margin: 20% 0% 5% 0%;
    }

    /* leaderboard */
    .endgame {
        height: 80%;
        flex-direction: row;
        justify-content: center;
        align-items: center;
        margin-top: 3%;
    }

    .top10 .score h5,
    .top10 .score span,
    .top3 .score h5,
    .top3 .score span {
        font-size: 1.2vw;
    }

    #score01 h5,
    #leaderboard_01,
    #leaderboard_01_score {
        font-size: 2.2vw;
    }

    .top3 {
        width: 55%;
        margin-right: 1%;
    }

    .top10 {
        width: 45%;
        margin-right: 2%;
    }

    .top10 .score {
        width: 100%;
        padding: 0.5em 0.9em;
        margin-top: 1%;
    }

    .leaderboard_name {
        width: 86%;
    }

    /* footer */
    .footer {
        background-color: transparent;
    }

    .footer_bg {
        background-image: url(./img/footer_bg.png);
        background-size: 100% 100%;
        background-position: center;
        background-repeat: no-repeat;
        padding-top: 1em;
    }

    .footer>div>div {
        justify-content: flex-end;
        align-items: flex-end;
    }

    .footer>div>div p:nth-child(2) {
        width: 83%;
        border-right: 1px solid #000000;
    }

    .footer>div>div p:nth-child(3) {
        width: 15%;
        margin-left: 1.75%;
    }

    .footer img {
        width: 30%;
    }

    .footer .icon {
        justify-content: flex-start;
        align-items: flex-start;
        width: 40%;
    }

    .icon div {
        width: 35%;
        padding: 0;
        background-color: transparent;
    }

    .icon div img {
        width: 100%;
        max-width: 50px;
        padding: 0;
        margin: 0;
    }

    .icon div img.rep {
        margin-left: 5%;
    }

    .icon_rep,
    .icon_arrow_white,
    .icon_plus_white {
        display: flex;
        justify-content: center;
    }

    .icon_plus_white {
        width: 50%;
    }

    .icon_rep div,
    .icon_arrow_white div,
    .icon_plus_white div {
        width: 100%;
        display: flex;
        flex-direction: row;
        justify-content: flex-start;
        align-items: center;
        background-color: #250e62;
        padding: 1.5em;
        border-radius: 1em;
    }

    .icon_rep div img {
        width: 100%;
        max-width: 45px;
        padding: 0;
        margin: 0;
    }

    .icon_rep div img.rep {
        margin-left: 5%;
    }

    .icon_rep div h5 {
        width: 100%;
        padding: 0em 0em 0em 1.5em;
    }

    .icon_arrow_white div,
    .icon_plus_white div {
        padding: 1em;
    }

    .icon_arrow_white div h5,
    .icon_plus_white div h5 {
        width: 100%;
        padding: 0em 1em 0em 1em;
    }

    .icon_arrow_white div img.arrow_white,
    .icon_plus_white div img.plus_white {
        width: 100%;
        max-width: 15px;
        padding: 0;
        margin: 0;
    }

    .icon_plus_white div img.plus_white {
        max-width: 22px;
    }

    /* cursor pointer */
    .ref,
    .rep,
    .top_popup .close_holder img,
    .close_game_btn,
    .treatment_tolerability,
    .word_search,
    .event_recordings,
    .play_button,
    .play_button_again,
    .find_out_more,
    .rep2,
    .side_effect1,
    .side_effect2,
    .side_effect3,
    .backtoside_effects,
    .dosing_regimen_click {
        cursor: pointer;
    }

    .treatment_tolerability {
        width: 80%;
        float: right;
    }

    /* nav bar */
    .header-main-menu img {
        width: 50%;
        max-width: 159px;
        float: right;
    }

    .header_top>a {
        width: 20%;
    }

    nav {
        top: 0;
        opacity: 1;
        background-color: transparent;
        display: flex;
        justify-content: center;
    }

    nav ul {
        width: 90%;
        flex-direction: row;
        height: auto;
        margin-top: 0;
    }

    nav ul.sub-menu li+li {
        margin-top: 0;
    }

    nav ul.sub-menu>li,
    nav ul>li:nth-child(2),
    nav ul>li:nth-child(4) {
        margin-top: 0;
        margin-right: 2%;
        width: 35%;
    }

    nav ul.sub-menu>li:nth-child(1),
    nav ul.sub-menu>li:nth-child(4),
    nav ul.sub-menu>li:nth-child(5),
    nav ul.sub-menu>li:nth-child(7) {
        width: 25%;
    }

    nav ul li {
        border-right: 1px solid #250e62;
        border-bottom: none;
        padding: 0 0.5em 0em 0em;
        text-transform: uppercase;
    }

    nav ul li:last-child {
        border-right: none;
    }

    nav ul li a {
        text-decoration: none;
        color: #250e62;
        font-size: 0.8vw;
    }

    nav li {
        line-height: 0.9;
    }

    /* submenu for navbar */
    #main-menu .submenu {
        display: flex;
        flex-direction: column;
        position: absolute;
        top: 100%;
        left: 0;
        margin-top: 0.5%;
        list-style-type: none;
        padding: 0;
        opacity: 0;
        z-index: -1;
        width: auto;
        pointer-events: none;
        transition: all 0.3s ease;
    }

    nav ul.sub-menu>li:nth-child(4) .submenu {
        margin-left: 35%;
    }

    nav ul.sub-menu>li:nth-child(7) .submenu {
        margin-left: 72%;
    }

    /* Style for submenu items */
    #main-menu .submenu .sub-nav-item {
        display: flex;
        align-items: flex-start;
    }

    #main-menu .submenu .sub-nav-link {
        text-decoration: none;
        padding: 1em;
        display: block;
        color: #250e62;
        background-color: #e4faff;
        text-align: left;
    }

    #main-menu .nav-item .submenu {
        transition: all 0.3s ease;
    }

    #main-menu .submenu .sub-nav-link:hover {
        pointer-events: auto;
        background-color: #250e62;
        color: #ffffff;
    }

    .sub-nav-item {
        border-right: none;
    }

    .sub-nav-link {
        width: 100%;
        min-width: 215px;
        max-width: 230px;
    }

    /* scrollbar */
    /* ===== Scrollbar CSS ===== */
    /* Firefox */
    * {
        scrollbar-width: thin;
        scrollbar-color: #666666 #ffffff;
    }

    /* Chrome, Edge, and Safari */
    *::-webkit-scrollbar {
        width: 1px;
    }

    *::-webkit-scrollbar-track {
        background: #ffffff;
    }

    *::-webkit-scrollbar-thumb {
        background-color: #ececec;
        border-radius: 2em;
        border: 1px solid #ffffff;
    }
}

@media screen and (min-width:800px) and (max-width:990px) {
    .max_desktop {
        width: 100% !important;
    }

    h2.home_h2,
    h2 span {
        /* font-size: 4vw; */
    }

    .smallerh3 {
        /* font-size: 1.5vw; */
    }

    h5 {
        font-size: 2.5vw;
    }

    sup {
        font-size: xx-small;
    }

    .disclaimer p,
    p.light,
    h5.light_small,
    h5.bold_small {
        font-size: 0.9vw;
    }

    ul.sub-menu {
        padding: 0.5em 1em;
    }

    .sub-nav-link {
        min-width: 150px;
        max-width: 200px;
    }

    .header-main-menu img {
        max-width: 140px;
    }

    .icon_rep div img {
        max-width: 40px;
    }

    .top_popup .close_holder img,
    .close_game_btn {
        width: 17px;
    }

    .div_popup>div:first-child,
    .treatment_padding {
        padding: 3em;
    }

    .icon_plus_white div img.plus_white {
        /* max-width: 25px; */
    }
}

@media screen and (min-width: 992px) {

    .blue_table_holder>div:first-child,
    .blue_table_holder>div:nth-child(2) {
        min-height: 177px;
    }
}

@media screen and (min-width: 1270px) {

    .blue_table_holder>div:first-child,
    .blue_table_holder>div:nth-child(2) {
        min-height: 200px;
    }

    .three_td_desktop {
        margin-right: 5%;
    }
}

@media screen and (min-width: 1350px) {

    .three_td_desktop {
        margin-right: 10%;
    }
}

@media screen and (min-width: 1600px) {

    .blue_table_holder>div:first-child,
    .blue_table_holder>div:nth-child(2) {
        min-height: 250px;
    }

    .icon_arrow_white div img.arrow_white,
    .icon_plus_white div img.plus_white {
        max-width: 20px;
    }

    .icon_rep div img {
        max-width: 60px;
    }
}

@media screen and (min-width: 1650px) {
    .three_td_desktop {
        justify-content: flex-start;
        margin-right: 0%;
    }
}

@media screen and (min-width:1921px) {

    .game li {
        font-size: 1vw;
    }

    .timer span {
        font-size: 1.8vw;
    }

    .header_popup_top .div_popup,
    .header_popup .div_popup {
        /* min-height: 800px !important; */
        max-height: 950px !important;
    }

}

@media screen and (min-width:2560px) {

    .header_popup_top .div_popup,
    .header_popup .div_popup {
        /* min-height: 1000px !important; */
        max-height: 1050px !important;
    }

}